Teaser 2684: How safe?

From The Sunday Times, 2nd March 2014 [link] [link]

Fed up with being burgled, George and Martha have bought a new safe. They remember its six-figure combination as three two-figure primes. Martha noted that the product of the six different digits of the combination was a perfect square, as was the sum of the six. George commented further that the six-figure combination was actually a multiple of the difference between that product and sum.

What is the six-figure combination?

[teaser2684]